Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Maleic Acid → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid maleate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Maleic Acid | HCID 444266 | — |
| 반응물 | SR142948A | HCID 5311451 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid maleate | HCID 70244983 | 34.2% |
반응 단계
0.1 g of the compound obtained in EXAMPLE 1' and 0.017 g of maleic acid are dissolved in the heated state in 2.3 ml of 2-propanol, and the mixture is concentrated under vacuum. The residue is dissolved in 0.3 ml of EtOH, this solution is poured into 30 ml of ether and the precipitate formed is drained. 0.04 g of the expected product is obtained, m.p.=260° C. (dec.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05925661 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-04bc1c6ca1d64c45a9f25db9982b6041 |
| 출처 메모 | uspto-grants-1999_07 |