Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid fumarate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Fumaric Acid | HCID 444972 | — |
| 반응물 | SR142948A | HCID 5311451 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid fumarate | HCID 70244564 | 21.4% |
반응 단계
0.1 g of the compound obtained in EXAMPLE 1' and 0.017 g of fumaric acid are dissolved in 1.5 ml of EtOH, 1.5 ml of DCM and 4 ml of MeOH, and the mixture is left stirring for 10 minutes at RT. It is partially concentrated under vacuum and crystallization is allowed to take place. 0.025 g of the expected product is obtained after draining and washing with EtOH, m.p.=243° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05925661 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-ea8888d1b7fa442992ab351310d3a3fe |
| 출처 메모 | uspto-grants-1999_07 |