Ethyl 3-(2-bromoethoxy)-2-methylbenzoate → Ethyl 3-(2-methylsulfonylthioethoxy)-2-methylbenzoate

HRID 582822노트

반응식

HRID 582822 반응식
Br[CH2:2][CH2:3][O:4][C:5]1[C:6]([CH3:16])=[C:7]([CH:13]=[CH:14][CH:15]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9].[CH3:17][S:18]([O-:21])(=[S:20])=[O:19].[K+]>C(O)C>[CH3:17][S:18]([S:20][CH2:2][CH2:3][O:4][C:5]1[C:6]([CH3:16])=[C:7]([CH:13]=[CH:14][CH:15]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9])(=[O:21])=[O:19]

참가 물질

4

반응물 2

HCID 15376195Ethyl 3-(2-bromoethoxy)-2-methylbenzoateHCID 23696406Potassium thiomethanesulfonate

생성물 1

HCID 15376196Ethyl 3-(2-methylsulfonylthioethoxy)-2-methylbenzoate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2 g (7 mmol) of ethyl 3-(2-bromoethoxy)-2-methylbenzoate and 1.1 g (7.3 mmol) of potassium thiomethanesulfonate are dissolved in 10 ml absolute ethanol. The reaction mixture is refluxed for 20 hours. The solvent is then distilled off and the residue taken up in methylene chloride and washed with water. The organic phase is dried over sodium sulfate and the solvent is removed. The product of value is purified by column chromatography.

후처리

  1. temperatureThe reaction mixture is refluxed for 20 hours
  2. distillationThe solvent is then distilled off
  3. washwashed with water
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customthe solvent is removed
  6. customThe product of value is purified by column chromatography

출처 및 근거

ORD 기록
ord-971a12ba684246ea9e0f633a678e70d6
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05925767

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