참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Chloro-1,2-benzoxazole | HCID 2779780 | — |
| 반응물 | Methyl(2-(morpholin-4-yl)ethyl)amine | HCID 14979282 | — |
| 생성물 | N-methyl-N-[2-(4-morpholinyl)ethyl]-1,2-benzisoxazol-3-amine | HCID 15453429 | 23.5% |
반응 단계
To a sealed tube was added 3-chloro-1,2-benzisoxazole (3.0 g) and N-methyl-N-[2-(4-morpholinyl)ethyl]-amine (12.7 g). The reaction was heated to 140° C. over 72 hours and then cooled to room temperature. The residue was partitioned between EtOAc and water, extracted again with EtOAc, and the organic phase was dried over MgSO4 and concentrated in vacuo. Flash column chromatography (silica gel) eluting with 1-3% MeOH/DCM provided the product (1.2 g), as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05925766 |
|---|
| 출처 데이터셋 | uspto-grants-1999_07 |
|---|
| ORD ID | ord-7a018fe6d1b2475e95ea4c203cd01652 |
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| 출처 메모 | uspto-grants-1999_07 |
|---|
