HCID 56999066, 화합물 → HCID 12916445, 화합물

HRID 582900노트

반응식

HRID 582900 반응식
[O:1]1[C@H:7]([CH2:8][CH2:9]CCCCCCCCCCCCC)[C@H:2]1[C:3]([O:5][CH3:6])=[O:4]>CO>[O:1]1[C@H:7]([CH2:8][CH3:9])[C@H:2]1[C:3]([O:5][CH3:6])=[O:4]

참가 물질

3

반응물 1

HCID 56999066HCID 56999066, 화합물

생성물 1

HCID 12916445HCID 12916445, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In 500 ml of methanol were dissolved 62.4 g (0.2 mol) of the methyl (2S,3R)-2,3-epoxyoctadecanoate (V-1) obtained in (3) above and 7.4 g (0.2 mol) of sodium hydroxide, and the solution was stirred for 3 hours. After confirming disappearance of the compound (V-1) by TLC, methanol was evaporated. The resulting concentrate was adjusted to pH 5 to 6 with 500 ml of diluted hydrochloric acid and extracted with 500 ml of ethyl acetate. After drying, ethyl acetate was evaporated, and the resulting crude crystals were recrystallized from a 5-fold volume of heptane to afford 42.6 g (0.15 mol; yield: 75%) of the title compound (V-2) (melting point: 186° C.).

출처 및 근거

ORD 기록
ord-8e659c68da8245fca8c3d1c9689cd8bb
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05925792

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