3-(2-(2-(Nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyl bromide → 5-Octyloxy-2-[4-(3-(2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyloxy)-2-fluorophenyl)pyrimidine

HRID 583000노트

반응식

HRID 583000 반응식
[CH2:1]([O:9][C:10]1[CH:11]=[N:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][C:17]=2[F:23])=[N:14][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[F:24][C:25]([F:53])([C:49]([F:52])([F:51])[F:50])[C:26]([F:48])([F:47])[C:27]([F:46])([F:45])[O:28][C:29]([F:44])([F:43])[C:30]([F:42])([F:41])[O:31][C:32]([F:40])([F:39])[CH2:33][O:34][CH2:35][CH2:36][CH2:37]Br>>[CH2:1]([O:9][C:10]1[CH:15]=[N:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:37][CH2:36][CH2:35][O:34][CH2:33][C:32]([O:31][C:30]([F:41])([F:42])[C:29]([F:43])([F:44])[O:28][C:27]([F:45])([F:46])[C:26]([F:47])([F:48])[C:25]([F:24])([F:53])[C:49]([F:52])([F:51])[F:50])([F:40])[F:39])=[CH:18][C:17]=2[F:23])=[N:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

3

반응물 2

HCID 218324923-(2-(2-(Nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyl bromideHCID 1358568185-Octyloxy-2-[4-hydroxy-2-fluorophenyl)pyrimidine

생성물 1

HCID 212253555-Octyloxy-2-[4-(3-(2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyloxy)-2-fluorophenyl)pyrimidine

실험 절차

The title compound was prepared essentially as in Example 1 by combining 5-octyloxy-2-[4-hydroxy-2-fluorophenyl)pyrimidine (1.5 g, 4.7 mmol, prepared from 2-fluoro-4-hydroxybenzamidine hydrobromide and (CH3)2NCH=C(OC8H17)CHO) with 3-(2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyl bromide (3.0 g, 5.4 mmol, Example 3). The reaction mixture was quenched with water, and the resulting crude product was further purified by recrystallization from ethanol, followed by Kugelrohr distillation (190-210° C. at 0.5 torr), to provide a yield of 2.85 g.

후처리

  1. customThe reaction mixture was quenched with water
  2. customthe resulting crude product was further purified by recrystallization from ethanol
  3. distillationfollowed by Kugelrohr distillation (190-210° C. at 0.5 torr)
  4. customto provide a yield of 2.85 g

출처 및 근거

ORD 기록
ord-0651762090b0496d9101eeac7eb4885b
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05928562

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