5-Hexyloxy-2-[4-(5-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)pentyloxy)phenyl]pyrimidine → HCID 21225397, 화합물

HRID 583002노트

반응식

HRID 583002 반응식
[CH2:1]([O:9][C:10]1[CH:11]=[N:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([F:23])[CH:17]=2)=[N:14][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(OC1C=NC(C2C=CC(O[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][O:49][CH2:50][C:51]([O:54][C:55]([F:68])([F:67])[C:56]([F:66])([F:65])[O:57][C:58]([F:64])([F:63])[C:59]([F:62])([F:61])[F:60])([F:53])[F:52])=CC=2)=NC=1)CCCCC>>[CH2:1]([O:9][C:10]1[CH:15]=[N:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][O:49][CH2:50][C:51]([O:54][C:55]([F:67])([F:68])[C:56]([F:65])([F:66])[O:57][C:58]([F:63])([F:64])[C:59]([F:60])([F:61])[F:62])([F:53])[F:52])=[C:18]([F:23])[CH:17]=2)=[N:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

3

반응물 2

HCID 212253415-Hexyloxy-2-[4-(5-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)pentyloxy)phenyl]pyrimidineHCID 135590745HCID 135590745, 화합물

생성물 1

HCID 21225397HCID 21225397, 화합물

실험 절차

The title compound was prepared essentially as in Example 1 by combining 5-octyloxy-2-[4-hydroxy-3-fluorophenyl)pyrimidine (1.5 g, 4.7 mmol) with 5-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)pentyl chloride (2.45 g, 5.1 mmol, Example 22). The reaction mixture was quenched with water, and the resulting crude product was further purified by recrystallization from ethanol, followed by Kugelrohr distillation (210° C. at 0.5 torr), to provide a yield of 2.6 g.

후처리

  1. customThe reaction mixture was quenched with water
  2. customthe resulting crude product was further purified by recrystallization from ethanol
  3. distillationfollowed by Kugelrohr distillation (210° C. at 0.5 torr)
  4. customto provide a yield of 2.6 g

출처 및 근거

ORD 기록
ord-cfa9e2faae37424b9c4631ac2b135637
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05928562

반응 노트

불러오는 중…