Pyridine → HCID 15220197, 화합물

HRID 583049노트

반응식

HRID 583049 반응식
N1C=CC=CC=1.[CH:7]1([C:10](Cl)=[O:11])[CH2:9][CH2:8]1.[NH2:13][C:14]1[CH:15]=[C:16]([C:21]2[C:25]([Cl:26])=[C:24]([O:27][CH:28]([F:30])[F:29])[N:23]([CH3:31])[N:22]=2)[CH:17]=[CH:18][C:19]=1[Cl:20]>O1CCCC1>[Cl:26][C:25]1[C:21]([C:16]2[CH:17]=[CH:18][C:19]([Cl:20])=[C:14]([NH:13][C:10]([CH:7]3[CH2:9][CH2:8]3)=[O:11])[CH:15]=2)=[N:22][N:23]([CH3:31])[C:24]=1[O:27][CH:28]([F:30])[F:29]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 77637Cyclopropanecarbonyl chlorideHCID 21226443HCID 21226443, 화합물

생성물 1

HCID 15220197HCID 15220197, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
50 °C

실험 절차

1.0 g (13 mmol) of pyridine and 0.7 g (6.5 mmol) of cyclopropanecarbonyl chloride were added to a solution of 2.0 g (6.5 mmol) of 3-(3-amino-4-chlorophenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole in 30 ml of tetrahydrofuran. The solution was stirred at room temperature overnight and at 50° C. for 2 hours, an then concentrated. The residue was taken up in ethyl acetate. The ethyl acetate was washed in succession with cold 1N hydrochloric acid, water and saturated sodium chloride solution, then dried over magnesium sulfate and finally concentrated. Yield: 2.2 g.

후처리

  1. concentrationan then concentrated
  2. washThe ethyl acetate was washed in succession with cold 1N hydrochloric acid, water and saturated sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. concentrationfinally concentrated

출처 및 근거

ORD 기록
ord-0c3472d59bf94270b789077c1807dc69
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05928999

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