Benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate → 2-(3-Amino-2-oxopyridin-1(2H)-yl)-N-isopentylacetamide

HRID 58321

반응식

HRID 58321 반응식
[CH2:1]([NH:6][C:7](=[O:27])[CH2:8][N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15]C(=O)OCC2C=CC=CC=2)[C:10]1=[O:26])[CH2:2][CH:3]([CH3:5])[CH3:4]>C(O)C.[Pd]>[NH2:15][C:11]1[C:10](=[O:26])[N:9]([CH2:8][C:7]([NH:6][CH2:1][CH2:2][CH:3]([CH3:4])[CH3:5])=[O:27])[CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 1

HCID 89926023Benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

생성물 1

HCID 621027802-(3-Amino-2-oxopyridin-1(2H)-yl)-N-isopentylacetamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

573 mg of benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate (ZED1020, 1.54 mmol) are dissolved under nitrogen atmosphere in 100 mL of ethanol. To this solution 50 mg of Pd/C (10%) is added and stirred under hydrogen atmosphere at atmosphere pressure for 1 h at RT. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. Green solid is obtained and it is suitable for further processing without purification.

후처리

  1. customThe catalysis is separated by filtration over silica gel, before the solvent
  2. customis removed in vacuo
  3. customGreen solid is obtained
  4. customit is suitable for further processing without purification

출처 및 근거

ORD 기록
ord-e04a6a6bdfb94eadbe3d12bb628ca028
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434763B2

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