Benzyl Bromide → HCID 54357009, 화합물

HRID 583376노트

반응식

HRID 583376 반응식
[NH2:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]([CH3:12])[C:3]=1[C:4]([OH:6])=[O:5].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+].[I-]>CC(C)=O>[CH2:13]([O:5][C:4](=[O:6])[C:3]1[C:7]([CH3:12])=[CH:8][CH:9]=[C:10]([CH3:11])[C:2]=1[NH2:1])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

6

반응물 4

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 30165Iodide IonHCID 2757742-amino-3,6-dimethylbenzoic acid

생성물 1

HCID 54357009HCID 54357009, 화합물수율 48%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 940 mg (5.73 mmol) of 2-amino-3,6-dimethylbenzoic acid, 0.750 ml (6.3 mmol) of benzyl bromide, 1.04 g (7.5mmole) of potassium carbonate and 40 mg (0.27mmole) of soium iodide in 20 ml of acetone was heated to reflux for 20 hr. The resulting mixture was then concentrated in vacuo and the residue was chronatoghed with EtOAc/Hexane (1:50) as eluant to provide 697 mg (48%) of the desired product as a yellow oil. Electrospray Mass Spec 256 (M+H).

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 20 hr
  3. concentrationThe resulting mixture was then concentrated in vacuo

출처 및 근거

ORD 기록
ord-1008da67a5e54197b2b7481a8f9f2134
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05929097

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