Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → 4-Ethynylbenzoyl-2(S)-phenylsulfonylamino-beta-alanine ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 4-Ethynylbenzoic acid | HCID 589706 | — |
| 반응물 | Ethyl 2(S)-phenylsulfonylamino-beta-alanine p-toluenesulfonate | HCID 86752459 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Ethynylbenzoyl-2(S)-phenylsulfonylamino-beta-alanine ethyl ester | HCID 86752458 | — |
반응 단계
4-Ethynylbenzoic acid (35-1) (3.10 g, 21.2 mmol), 35-2 (8.58 g, 19.3 mmol), NMM (8.49 mL, 7.72 mmol), HOBT (3.39 g, 25.1 mmol), and EDC (4.81 g, 25.1 mmol) were combined in 96 mL DMF and stirred overnight. The reaction was concentrated, residue was diluted with EtOAc and washed with water (2×) and brine, dried (Na2SO4), filtered, and concentrated. Flash chromatography (silica, 45-50% EtOAc/Hexane) gave 35-3 as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05929120 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-268a8eabed7640b0a9ec915cc4429c22 |
| 출처 메모 | uspto-grants-1999_07 |