Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-Amino-4-methoxy-benzenesulfonic acid 3,4,5-trimethoxy-phenyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3,4,5-Trimethoxyphenol | HCID 69505 | — |
| 반응물 | 3-Amino-4-methoxyphenylsulphonyl fluoride | HCID 96952 | — |
| 반응물 | t-Butylammonium Iodide | HCID 22344722 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Amino-4-methoxy-benzenesulfonic acid 3,4,5-trimethoxy-phenyl ester | HCID 9820655 | 35% |
반응 단계
A solution of 3,4,5-trimethoxyphenol (505.7 mg, 2.75 mmol) in dichloromethane (28 mL) was treated sequentially with triethylamine (1.2 mL), 4-methoxymetanilyl fluoride (572.5 mg, 2.75 mmol), and tert-butylammonium iodide (106 mg, 0.287 mmol), stirred overnight, and washed once with 1M Na2CO3. The organic layer was separated, dried (MgSO4), filtered, and concentrated. Chromatography of the concentrate on silica gel with 40% ethyl acetate/hexanes provided 356 mg of the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06924304B2 |
| 출처 데이터셋 | uspto-grants-2005_08 |
| ORD ID | ord-1e4d61a307c34e5ab4b3ba24047a90d2 |
| 출처 메모 | uspto-grants-2005_08 |