Piperazine → 1-(3-Chloro-5-(trifluoromethyl)phenyl)piperazine

반응식

Cl[C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[Cl:8][C:6]1[CH:7]=[C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=1

참가 물질

반응물 2

HCID 4837Piperazine

HCID 353611,3-Dichloro-5-(trifluoromethyl)benzene

생성물 1

HCID 223451951-(3-Chloro-5-(trifluoromethyl)phenyl)piperazine수율 52.1%

실험 절차

Beginning with 3,5-dichlorobenzotrifluoride (500 mg, 2.32 mmol) and piperazine (1 g, 11.6 mmol), 320 mg of the title compound was recovered by the procedure described in Example 1.

출처 및 근거

ORD 기록: ord-4f196782448f469e8575e99e3ce0db68
출처 데이터셋: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06924374B2

반응 노트

불러오는 중…