Piperazine → 1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine

HRID 584084노트

반응식

HRID 584084 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([Cl:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[Cl:12][C:5]1[CH:4]=[CH:3][C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:7][C:6]=1[C:8]([F:11])([F:10])[F:9]

참가 물질

3

반응물 2

HCID 4837PiperazineHCID 679594-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene

생성물 1

HCID 27781371-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine수율 78.2%

실험 절차

Beginning with 5-bromo-2-chlorobenzotrifluoride (602 mg) and piperazine (1 g), 480 mg of the title compound was recovered by the procedure described in Example 1.

출처 및 근거

ORD 기록
ord-aaf69014045a4df48cfb5c6eab8843aa
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06924374B2

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