(3,5-Di-tert-butyl-2-propoxyphenyl)boronic acid → 3-(3',5'-di-tert-butyl-6-methoxy-2'-propoxy-3-biphenylyl)acrylic Acid

HRID 584279노트

반응식

HRID 584279 반응식
Br[C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]([O:14]CC)=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH2:17]([O:20][C:21]1[C:26]([C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:25][C:24]([C:31]([CH3:34])([CH3:33])[CH3:32])=[CH:23][C:22]=1B(O)O)[CH2:18][CH3:19]>>[C:27]([C:26]1[C:21]([O:20][CH2:17][CH2:18][CH3:19])=[C:22]([C:2]2[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[C:4]([CH:10]=[CH:11][C:12]([OH:14])=[O:13])[CH:3]=2)[CH:23]=[C:24]([C:31]([CH3:34])([CH3:33])[CH3:32])[CH:25]=1)([CH3:30])([CH3:28])[CH3:29]

참가 물질

3

반응물 2

HCID 22345485(3,5-Di-tert-butyl-2-propoxyphenyl)boronic acidHCID 69792510Ethyl 3-(3-bromo-4-methoxyphenyl)acrylate

생성물 1

HCID 542842693-(3',5'-di-tert-butyl-6-methoxy-2'-propoxy-3-biphenylyl)acrylic Acid수율 80.8%

실험 절차

In a manner similar to that of Example 1(c), by reaction of 1.0 g (3.5 mmol) of ethyl 3-(3-bromo-4-methoxyphenyl)acrylate obtained in Example 13(d) with 1.54 g (5.26 mmol) of 2-propyloxy-3,5-di-tert-butylphenylboronic acid obtained in Example 39(b), 1.20 g (76%) of the expected compound was obtained in the form of a white powder having a melting point of 107°-109° C.

출처 및 근거

ORD 기록
ord-64089a86c4944762969594ab0f844154
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06924388B2

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