2-Chloroethyl methyl ether → 1-Bromo-2-ethyl-5-ethoxymethoxybenzene

반응식

[Br:1][C:2]1[CH:3]=[C:4]([OH:10])[CH:5]=[CH:6][C:7]=1[CH2:8][CH3:9].[CH3:11][O:12][CH2:13][CH2:14]Cl>>[Br:1][C:2]1[CH:3]=[C:4]([O:10][CH2:11][O:12][CH2:13][CH3:14])[CH:5]=[CH:6][C:7]=1[CH2:8][CH3:9]

참가 물질

반응물 2

HCID 123162-Chloroethyl methyl ether

HCID 223455883-Bromo-4-ethylphenol

생성물 1

HCID 223456161-Bromo-2-ethyl-5-ethoxymethoxybenzene

실험 절차

In a manner similar to that of Example 1(e), by reacting 13 g (65 mmol) of 3-bromo-4-ethylphenol with 6.7 ml (72 mmol) of methoxyethyl chloride, and after purification by chromatography on a column of silica eluted with a mixture of heptane and ethyl acetate (90/10), 12 g (76%) of the expected product are obtained in the form of a yellow oil.

후처리

customafter purification by chromatography on a column of silica
washeluted with a mixture of heptane and ethyl acetate (90/10), 12 g (76%) of the expected product
customare obtained in the form of a yellow oil

출처 및 근거

ORD 기록: ord-4c73d5adae1e4cc19265abee89b64b8f
출처 데이터셋: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06924400B2

반응 노트

불러오는 중…