Thionyl Chloride → 4-(4-Chloromethyl-2-methoxyphenoxymethyl)-2-(2-furyl)-5-methyloxazole

HRID 584402

반응식

HRID 584402 반응식
S(Cl)([Cl:3])=O.[O:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[C:10]1[O:11][C:12]([CH3:27])=[C:13]([CH2:15][O:16][C:17]2[CH:24]=[CH:23][C:20]([CH2:21]O)=[CH:19][C:18]=2[O:25][CH3:26])[N:14]=1>O1CCCC1>[Cl:3][CH2:21][C:20]1[CH:23]=[CH:24][C:17]([O:16][CH2:15][C:13]2[N:14]=[C:10]([C:6]3[O:5][CH:9]=[CH:8][CH:7]=3)[O:11][C:12]=2[CH3:27])=[C:18]([O:25][CH3:26])[CH:19]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 537700494-[2-(2-Furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzyl alcohol

생성물 1

HCID 223445974-(4-Chloromethyl-2-methoxyphenoxymethyl)-2-(2-furyl)-5-methyloxazole수율 85%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Thionyl chloride (2.59 g) was added dropwise to a stirred suspension of 4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzyl alcohol (6.30 g) in tetrahydrofuran (100 ml) at 0° C. After stirring at room temperature for 1 hours, the reaction mixture was poured onto ice to give 4-(4-chloromethyl-2-methoxyphenoxymethyl)-2-(2-furyl)-5-methyloxazole as crystals (5.67 g, yield 85%).

후처리

  1. additionthe reaction mixture was poured onto ice

출처 및 근거

ORD 기록
ord-6b7d66beda504c919f13f5bb50712128
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06924300B2

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