Thionyl Chloride → 4-(4-Chloromethyl-2-methoxyphenoxymethyl)-5-methyl-2-phenyloxazole

HRID 584404

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[N:14]=[C:15]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:16][C:17]=1[CH3:18])[CH2:6]O.S(Cl)([Cl:27])=O>>[Cl:27][CH2:6][C:5]1[CH:8]=[CH:9][C:10]([O:11][CH2:12][C:13]2[N:14]=[C:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[O:16][C:17]=2[CH3:18])=[C:3]([O:2][CH3:1])[CH:4]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 573158203-Methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol

생성물 1

HCID 223446094-(4-Chloromethyl-2-methoxyphenoxymethyl)-5-methyl-2-phenyloxazole수율 126.4%

실험 절차

In substantially the same manner in Reference Example 94, 3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol (6.00 g) was reacted with thionyl chloride (1.58 g) to obtain 4-(4-chloromethyl-2-methoxyphenoxymethyl)-5-methyl-2-phenyloxazole (5.77 g, yield 91%) as crystals.

출처 및 근거

ORD 기록: ord-a41e1f546806444ba5c78adb1444abab
출처 데이터셋: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06924300B2

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