2-Chloro-6-ethoxyquinoline-3-carbaldehyde → 2-Chloro-6-ethoxyquinoline-3-carbaldehyde-O-methyl-oxime

HRID 584665노트

반응식

HRID 584665 반응식
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH2:15][CH3:16])[CH:8]=2)[N:3]=1.Cl.[CH3:18][O:19][NH2:20].C(O)C>>[CH3:18][O:19][N:20]=[CH:12][C:11]1[C:2]([Cl:1])=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([O:14][CH2:15][CH3:16])=[CH:6][CH:5]=2

참가 물질

3

반응물 2

HCID 7886582-Chloro-6-ethoxyquinoline-3-carbaldehydeHCID 22341071HCID 22341071, 화합물

생성물 1

HCID 738840702-Chloro-6-ethoxyquinoline-3-carbaldehyde-O-methyl-oxime

실험 절차

To a solution of 2-chloro-6-ethoxyquinoline-3-carbaldehyde (0.235 g, 1.0 mmol) in ethanol O-methylhydroxylamine hydrochloride (0.10 g, 1.1 mmol) was added. The reaction mixture was heated to reflux for 0.5 hours. After cooling to room temperature the precipitated compound was filtered and dried. Yield 180 mg. M.p. 142-4° C.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 0.5 hours
  3. filtrationwas filtered
  4. customdried

출처 및 근거

ORD 기록
ord-a54f64eba8e247f0ae17a36478d376c7
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927214B1

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