1-Ethynyl-2-fluorobenzene → 2-(2-Fluoro-phenylethynyl)-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

HRID 584700노트

반응식

HRID 584700 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:13])[C:8](Br)=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2].[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[F:22])#[CH:15]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:13])[C:8]([C:15]#[C:14][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 6433581-Ethynyl-2-fluorobenzeneHCID 13897513ethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylate

생성물 1

HCID 98789802-(2-Fluoro-phenylethynyl)-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

실험 절차

The title compound, MS: m/e=287.4 (M+H+) was prepared in accordance with the general method of example 1b from 2-bromo-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester and 1-ethynyl-2-fluorobenzene.

출처 및 근거

ORD 기록
ord-ad2bb9a9553e469788bac431ee7c2a3b
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927232B2

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