2-Acetylbutyrolactone → 3-[1-(3-Mesityl-2-methylanilino)ethylidene]tetrahydro-2-furanone

HRID 584815

반응식

HRID 584815 반응식
[C:1]1([CH3:17])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[C:9]1[C:10]([CH3:16])=[C:11]([CH:13]=[CH:14][CH:15]=1)[NH2:12].[C:18]([CH:21]1[CH2:26][CH2:25][O:24][C:22]1=[O:23])(=O)[CH3:19]>C(O)C>[C:1]1([CH3:17])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[C:9]1[C:10]([CH3:16])=[C:11]([CH:13]=[CH:14][CH:15]=1)[NH:12][C:18](=[C:21]1[CH2:26][CH2:25][O:24][C:22]1=[O:23])[CH3:19]

참가 물질

4

반응물 2

HCID 106012-AcetylbutyrolactoneHCID 222495383-Mesityl-2-methylaniline

생성물 1

HCID 695835283-[1-(3-Mesityl-2-methylanilino)ethylidene]tetrahydro-2-furanone수율 95.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3-mesityl-2-methylaniline (5.0 g, 22 mmol) and α-acetyl-γ-butyrolactone (14.2 g, 0.11 mol) in ethanol (100 mL) was heated at reflux for three days. The mixture was evaporated, and the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (7.08 g) as white crystals.

후처리

  1. temperatureat reflux for three days
  2. customThe mixture was evaporated
  3. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-aa75fcc7501d4cd68fb8d5995ad2fc31
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927221B2

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