HCID 22341850, 화합물 → HCID 22182264, 화합물
반응식
[CH3:1][C:2]1([CH3:13])[CH2:7][C:6](=[O:8])[CH2:5][C:4]([CH2:11][CH3:12])([CH2:9][CH3:10])[NH:3]1>CO>[CH3:13][C:2]1([CH3:1])[CH2:7][CH:6]([OH:8])[CH2:5][C:4]([CH2:9][CH3:10])([CH2:11][CH3:12])[NH:3]1참가 물질
3
실험 절차
To a solution of 15.8 g (0.086 mol) 2,2-dimethyl-6,6-diethyl-4-oxopiperidine in 50 ml methanol 2.2 g (0.06 M) sodium borohydride are added in portions. The temperature is kept below 30° C. After stirring over night methanol is removed under vacuum and the residue is diluted with 20 ml 2N-NaOH. The solution is extracted with ethylacetate. The combined extracts are washed with saturated NaCl solution, dried over MgSO4 and dried under vacuum at 60° C./50 mbar until a constant weight is achieved. 15.8 g (99%) 2,2-dimethyl-6,6-diethyl-4-hydroxypiperidine are obtained as yellowish oil.
후처리
- customis kept below 30° C
- customis removed under vacuum
- additionthe residue is diluted with 20 ml 2N-NaOH
- extractionThe solution is extracted with ethylacetate
- washThe combined extracts are washed with saturated NaCl solution
- dry with materialdried over MgSO4
- customdried under vacuum at 60° C./50 mbar until a constant weight
출처 및 근거
- ORD 기록
- ord-5ccbba85043447e5a9e65d5d28abde8e
- 출처 데이터셋
- uspto-grants-2005_08
- 특허 번호
- US06927295B2
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