4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 2-Nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenol

HRID 584865

반응식

HRID 584865 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[F:12][C:13]1[C:20]([F:21])=[C:19]([C:22]([F:25])([F:24])[F:23])[C:18]([F:26])=[C:17]([F:27])[C:14]=1[CH2:15]Br>CN(C=O)C>[N+:9]([C:4]1[CH:3]=[C:2]([NH:1][CH2:15][C:14]2[C:17]([F:27])=[C:18]([F:26])[C:19]([C:22]([F:23])([F:25])[F:24])=[C:20]([F:21])[C:13]=2[F:12])[CH:7]=[CH:6][C:5]=1[OH:8])([O-:11])=[O:10]

참가 물질

4

반응물 2

HCID 1271374-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromideHCID 34174194-Amino-2-Nitrophenol

생성물 1

HCID 104300752-Nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenol수율 40.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

According to the similar procedure in Synthesis Example 1, by using 4-amino-2-nitrophenol (1.00 g, 6.49 mmole), DMF (30 ml), TEA (0.5 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (1.30 g, 7.78 mmole), 1.00 g (40.0% yield) of 2-nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenol was obtained as a reddish solid.:

후처리

  1. customAccording to the similar procedure in Synthesis Example 1

출처 및 근거

ORD 기록
ord-56c55971ff944e42afbb4057312797f6
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927303B2

연결된 노트

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