Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Ethanoyloxy-5-tert-butoxycarbonylaminobenzoic acid → Acetyl-5-aminosalicylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Ethanoyloxy-5-tert-butoxycarbonylaminobenzoic acid | HCID 22341901 | — |
| 용매 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 생성물 | Acetyl-5-aminosalicylic acid | HCID 13140652 | 97.4% |
반응 단계
The mixture of 2-ethanoyloxy-5-tert-butoxycarbonylaminobenzoic acid (1.01 g, 3.42 mmole) in TFA/CH2Cl2 (20.0 ml. 1:1 v/v) was stirred for 30 min at room temperature. After the reaction mixture was concentrated, the residue was dissolved in ether. The resulting residue was recrystallized from ethyl acetate/hexane to give 0.65 g (97% yield) of 2-ethanoyloxy-5-aminobenzoic acid as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06927303B2 |
| 출처 데이터셋 | uspto-grants-2005_08 |
| ORD ID | ord-edad203dccf546b3b4e7ca003c472955 |
| 출처 메모 | uspto-grants-2005_08 |