4-Butoxybenzoyl chloride → 4-Butoxy-N-[4'-(2,4-dioxothiazolidin-5-ylmethyl)-biphenyl-3-ylmethyl]-N-methylbenzamide

HRID 584972노트

반응식

HRID 584972 반응식
[CH3:1][NH:2][CH2:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH:17]3[S:21][C:20](=[O:22])[NH:19][C:18]3=[O:23])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1.[CH2:24]([O:28][C:29]1[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=1)[CH2:25][CH2:26][CH3:27]>>[CH2:24]([O:28][C:29]1[CH:37]=[CH:36][C:32]([C:33]([N:2]([CH2:3][C:4]2[CH:5]=[C:6]([C:10]3[CH:11]=[CH:12][C:13]([CH2:16][CH:17]4[S:21][C:20](=[O:22])[NH:19][C:18]4=[O:23])=[CH:14][CH:15]=3)[CH:7]=[CH:8][CH:9]=2)[CH3:1])=[O:34])=[CH:31][CH:30]=1)[CH2:25][CH2:26][CH3:27]

참가 물질

3

반응물 2

HCID 1185614-Butoxybenzoyl chlorideHCID 120854865-(3'-Methylaminomethylbiphenyl-4-ylmethyl)thiazolidine-2,4-dione

생성물 1

HCID 102787684-Butoxy-N-[4'-(2,4-dioxothiazolidin-5-ylmethyl)-biphenyl-3-ylmethyl]-N-methylbenzamide

실험 절차

In a manner similar to that of Example 37(e), by reacting 500 mg (1.5 mmol) of 5-(3′-methylaminomethylbiphenyl-4-ylmethyl)thiazolidine-2,4-dione with 290 μl (1.5 mmol) of 4-butoxybenzoyl chloride, and after purification, 550 mg (83%) of 4-20 butoxy-N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylbenzamide are obtained in the form of a white solid with a melting point of 116° C.

후처리

  1. customafter purification, 550 mg (83%) of 4-20 butoxy-N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylbenzamide
  2. customare obtained in the form of a white solid with a melting point of 116° C.

출처 및 근거

ORD 기록
ord-3e8882921a9f4376ad27e3d7cb0e5661
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927228B2

반응 노트

불러오는 중…