4-Formylphenylboronic Acid → 3'-Methylaminobiphenyl-4-carbaldehyde

반응식

Br[C:2]1[CH:3]=[C:4]([NH:8][CH3:9])[CH:5]=[CH:6][CH:7]=1.[CH:10]([C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1)=[O:11]>>[CH3:9][NH:8][C:4]1[CH:3]=[C:2]([C:15]2[CH:16]=[CH:17][C:12]([CH:10]=[O:11])=[CH:13][CH:14]=2)[CH:7]=[CH:6][CH:5]=1

참가 물질

반응물 2

HCID 5910734-Formylphenylboronic Acid

HCID 70182993-Bromo-N-methylaniline

생성물 1

HCID 13945243'-Methylaminobiphenyl-4-carbaldehyde수율 60%

실험 절차

In a manner similar to that of Example 1(e), by reacting 4.3 g (23.2 mmol) of (3-bromophenyl)-methylamine with 5.2 g (34.8 mmol) of 4-formylbenzene-boronic acid, 2.9 g (60%) of the expected product are obtained.

출처 및 근거

ORD 기록: ord-2d7d3c3cd6ac4d5db5a1e68f2c32096a
출처 데이터셋: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06927228B2

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