Tert-butyl 6-(hydroxymethyl)-2-naphthylcarbamate → Tert-butyl 6-formyl-2-naphthylcarbamate

HRID 585301노트

반응식

HRID 585301 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:7]=[CH:6]2>ClCCl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:18])([CH3:17])[CH3:19])[CH:7]=[CH:6]2)=[O:1]

참가 물질

4

반응물 1

HCID 22340343Tert-butyl 6-(hydroxymethyl)-2-naphthylcarbamate

생성물 1

HCID 22340481Tert-butyl 6-formyl-2-naphthylcarbamate수율 89.5%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

The tert-butyl 6-(hydroxymethyl)-2-naphthylcarbamate (1.00 g, 3.66 mmol) obtained in the above 2) was dissolved in dichloromethane (18 ml), manganese dioxide (1.59 g, 18.3 mmol) was added thereto, and the mixture was stirred at room temperature for 4 hours. The insolubles were filtered, the filtrate was concentrated under reduced pressure., and crystallized from diisopropyl ether to obtain tert-butyl 6-formyl-2-naphthylcarbamate (889 mg) as a white powder.

후처리

  1. filtrationThe insolubles were filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. custom, and crystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-654f0be8e27246e0b6ec635b9926ce0d
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06930185B2

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