Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-(Cyclopropylcarbonyl)benzeneacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | [4-(4-Chloro-1-oxobutyl)]-N-methoxy-N-methyl benzeneacetamide | HCID 9857023 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(Cyclopropylcarbonyl)benzeneacetic acid | HCID 193731 | 95% |
반응 단계
Add purified [4-(4-chloro-1-oxobutyl)]-N-methoxy-N-methyl-benzeneacetamide (9.4 g, 330 mmol) to a solution of potassium hydroxide (22.0 g) in ethanol (160 mL). Stir 18 hours. Pour the solution into dilute hydrochloric acid (30 mL of concentrated hydrochloric acid in 500 mL of water). Extract the solution with three 500-mL portions of ethyl acetate. Dry the combined organic phases over anhydrous magnesium sulfate and concentrate to give the title compound (6.4 g, 95%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06930197B2 |
| 출처 데이터셋 | uspto-grants-2005_08 |
| ORD ID | ord-04aea1ae100e4c65be9c1c7b95b2904b |
| 출처 메모 | uspto-grants-2005_08 |