Hydrochloric Acid → 4-(Cyclopropylcarbonyl)benzeneacetic acid

HRID 585347

반응식

HRID 585347 반응식
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](N(OC)C)=[O:15])=[CH:9][CH:8]=1)=[O:6].[OH-:20].[K+].Cl>C(O)C>[CH:4]1([C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH2:13][C:14]([OH:15])=[O:20])=[CH:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 9857023[4-(4-Chloro-1-oxobutyl)]-N-methoxy-N-methyl benzeneacetamide

생성물 1

HCID 1937314-(Cyclopropylcarbonyl)benzeneacetic acid수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Add purified [4-(4-chloro-1-oxobutyl)]-N-methoxy-N-methyl-benzeneacetamide (9.4 g, 330 mmol) to a solution of potassium hydroxide (22.0 g) in ethanol (160 mL). Stir 18 hours. Pour the solution into dilute hydrochloric acid (30 mL of concentrated hydrochloric acid in 500 mL of water). Extract the solution with three 500-mL portions of ethyl acetate. Dry the combined organic phases over anhydrous magnesium sulfate and concentrate to give the title compound (6.4 g, 95%).

후처리

  1. additionAdd
  2. extractionExtract the solution with three 500-mL portions of ethyl acetate
  3. dry with materialDry the combined organic phases over anhydrous magnesium sulfate
  4. concentrationconcentrate

출처 및 근거

ORD 기록
ord-04aea1ae100e4c65be9c1c7b95b2904b
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06930197B2

연결된 노트

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