1-(4-Fluorophenyl)piperazine → HCID 22339237, 화합물

HRID 585391

반응식

HRID 585391 반응식
[CH:1]1[C:13]2[N:12]([CH:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:17]([C:24](=[O:35])[C:25]4[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([O:33][CH3:34])[CH:26]=4)[CH:16]([CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]O)[CH2:15]3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[F:42][C:43]1[CH:48]=[CH:47][C:46]([N:49]2[CH2:54][CH2:53][NH:52][CH2:51][CH2:50]2)=[CH:45][CH:44]=1>>[CH3:34][O:33][C:27]1[CH:26]=[C:25]([CH:30]=[CH:29][C:28]=1[O:31][CH3:32])[C:24]([N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:14]([N:12]2[C:11]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[C:5]3[C:13]2=[CH:1][CH:2]=[CH:3][CH:4]=3)[CH2:15][CH:16]1[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][N:52]1[CH2:51][CH2:50][N:49]([C:46]2[CH:45]=[CH:44][C:43]([F:42])=[CH:48][CH:47]=2)[CH2:54][CH2:53]1)=[O:35]

참가 물질

3

반응물 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 223392335-[4-(9H-9-Carbazolyl)-1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-2-quinolinyl]-1-pentanol

생성물 1

HCID 22339237HCID 22339237, 화합물수율 51.2%

실험 절차

Starting with 5-[4-(9H-9-carbazolyl)-1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-2-quinolinyl]-1-pentanol (0.13 g, 0.22 mmol) prepared in Example 135 and 4-(4-fluorophenyl)piperazine (79 mg, 0.44 mmol), the same procedure as shown in Example 136 was repeated to give the titled compound (0.08 g, yield: 51%) as a white crystal (cis:trans=4:1).

출처 및 근거

ORD 기록
ord-e62ec86fe7db49bc97eab548353d5ccf
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06930104B2

연결된 노트

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