Pentafluorobenzaldehyde → Methyl(s)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(pentafluorobenzylamino)propionate

HRID 585532

반응식

HRID 585532 반응식
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10](C)=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C@H:24]([NH:30]CC2C=CC(F)=CC=2)[C:25]([O:27][CH2:28]C)=[O:26])=[CH:19][CH:18]=1.[F:39][C:40]1[C:45]([CH:46]=O)=[C:44]([F:48])[C:43]([F:49])=[C:42]([F:50])[C:41]=1[F:51]>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:14][CH2:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][C@H:24]([NH:30][CH2:46][C:45]2[C:40]([F:39])=[C:41]([F:51])[C:42]([F:50])=[C:43]([F:49])[C:44]=2[F:48])[C:25]([O:27][CH3:28])=[O:26])=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 69558PentafluorobenzaldehydeHCID 12149026Ethyl(S)-3-[4-[2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy]phenyl]-2-(4-fluorobenzylamino)propionate

생성물 1

HCID 131725071Methyl(s)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(pentafluorobenzylamino)propionate

실험 절차

In the same manner as in Example 7, 433.0 mg of the title compound was obtained as colorless oil from 591.2 mg of Referential Compound 3 and 250 μL of pentafluorobenzaldehyde.

출처 및 근거

ORD 기록
ord-67037af6163c42c3b87c648363bd3c51
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06933309B2

연결된 노트

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