Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminopyridine → 4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminopyridine | HCID 1727 | — |
| 반응물 | 2-Chloro-1-methylpyridinium iodide | HCID 167069 | — |
| 반응물 | 4-(Tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid | HCID 22337379 | — |
| 생성물 | 4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide | HCID 22337377 | 67.5% |
반응 단계
By a similar reaction operation as in Starting Material Synthetic Example 53 using 4-(tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid (1.00 g), 4-aminopyridine (321 mg) and 2-chloro-1-methylpyridinium iodide (949 mg), the objective 4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide (834 mg) was obtained as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06933305B2 |
| 출처 데이터셋 | uspto-grants-2005_08 |
| ORD ID | ord-377a95a185fe48a086ff3b6818dac67d |
| 출처 메모 | uspto-grants-2005_08 |