Thionyl Chloride → 2-(4-Chlorophenyl)-2-methylpropanoyl chloride

HRID 585940노트

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HRID 585940 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9](O)=[O:10])=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>C1(C)C=CC=CC=1.CCCCCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9]([Cl:16])=[O:10])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 804062-(4-Chlorophenyl)-2-methylpropionic acid

생성물 1

HCID 135368632-(4-Chlorophenyl)-2-methylpropanoyl chloride수율 98%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8058Hexane용매

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온도
80 °C

실험 절차

2-(4-Chlorophenyl)-2-methylpropanoic acid (3.85 g, 19.4 mmol) in toluene (5 mL) was treated with thionyl chloride (5.00 g, 3.1 mL) and heated at 80° C. for 2 hours. The cooled solution was concentrated under reduced pressure to provide a yellow oil containing a crystalline residue. The mixture was dissolved in hexane, filtered and the filtrate concentrated to provide the compound as a pale yellow oil (4.10 g, 98%).

후처리

  1. concentrationThe cooled solution was concentrated under reduced pressure
  2. customto provide a yellow oil
  3. additioncontaining a crystalline residue
  4. filtrationfiltered
  5. concentrationthe filtrate concentrated

출처 및 근거

ORD 기록
ord-9168c5a574764f45b2fb613c5cc5949e
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06933311B2

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