6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 1-(2,3-dihydro-1H-inden-5-yl)-2-oxopyrrolidine-3-carboxylic acid

HRID 58595

반응식

HRID 58595 반응식
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[CH2:13]1[C:21]2[C:16](=[CH:17][C:18]([NH2:22])=[CH:19][CH:20]=2)[CH2:15][CH2:14]1>C(O)C>[CH2:13]1[C:21]2[C:16](=[CH:17][C:18]([N:22]3[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]3=[O:11])=[CH:19][CH:20]=2)[CH2:15][CH2:14]1

참가 물질

4

반응물 2

HCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dioneHCID 90496Indan-5-amine

생성물 1

HCID 246886971-(2,3-dihydro-1H-inden-5-yl)-2-oxopyrrolidine-3-carboxylic acid수율 71.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 2,3-dihydro-1H-inden-5-amine (0.593 g; 4.36 mmol) in ethanol (3 mL). 1-(2,3-dihydro-1H-inden-5-yl)-2-oxopyrrolidine-3-carboxylic acid 0.255 g (71%) was obtained as a white solid.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-dd8884cb3ecb43a8ae271bc771ede609
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434722B2

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