6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 1-(3,5-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid

HRID 58596

반응식

HRID 58596 반응식
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[F:13][C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([F:21])[CH:20]=1)[NH2:17]>C(O)C>[F:13][C:14]1[CH:15]=[C:16]([N:17]2[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]2=[O:11])[CH:18]=[C:19]([F:21])[CH:20]=1

참가 물질

4

반응물 2

HCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dioneHCID 965953,5-Difluoroaniline

생성물 1

HCID 246892091-(3,5-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid수율 48%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 3,5-difluoroaniline (0.575 g; 4.36 mmol) in ethanol (3 mL). 1-(3,5-difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid 0.167 g (48%) was obtained as a white solid.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-6747e784b02f4e8eadb693597e86eadd
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434722B2

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