3,4-Dimethylaniline → 1-(3,4-Dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid

HRID 58597

반응식

HRID 58597 반응식
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[CH3:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[CH3:21])[NH2:17]>C(O)C>[CH3:13][C:14]1[CH:15]=[C:16]([N:17]2[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]2=[O:11])[CH:18]=[CH:19][C:20]=1[CH3:21]

참가 물질

4

반응물 2

HCID 72483,4-DimethylanilineHCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione

생성물 1

HCID 242752121-(3,4-Dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid수율 86.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 3,4-dimethylaniline (0.540 g; 4.36 mmol) in ethanol (3 mL). 1-(3,4-dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid 0.292 g (86%) was obtained as a white solid.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-262dbf38dde742b0b51facbf862dca32
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434722B2

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