Di(succinimido) carbonate → methyl 4-({[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}amino)-1H-indazole-1-carboxylate

HRID 586066노트

반응식

HRID 586066 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][N:6]2[C:11]([O:13][CH3:14])=[O:12].[O:15]=[C:16]1[CH2:20][CH2:19][C:18](=[O:21])[N:17]1[O:22][C:23](ON1C(=O)CCC1=O)=[O:24]>C(#N)C>[O:15]=[C:16]1[CH2:20][CH2:19][C:18](=[O:21])[N:17]1[O:22][C:23]([NH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][N:6]2[C:11]([O:13][CH3:14])=[O:12])=[O:24]

참가 물질

4

반응물 2

HCID 676246Di(succinimido) carbonateHCID 22032652methyl 4-amino-1H-indazole-1-carboxylate

생성물 1

HCID 11313556methyl 4-({[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}amino)-1H-indazole-1-carboxylate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Methyl 4-amino-1H-indazole-1-carboxylate (1.9 g, 10 mmol) and 1-({[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}oxy)-2,5-pyrrolidinedione (2.8 g, 11 mmol) were combined in acetonitrile (100 mL), stirred for 48 hours at ambient temperature, and filtered. The filter cake was washed with acetonitrile (10 mL) and dried under reduced pressure at ambient temperature to provide the title compound.

후처리

  1. filtrationfiltered
  2. washThe filter cake was washed with acetonitrile (10 mL)
  3. customdried under reduced pressure at ambient temperature

출처 및 근거

ORD 기록
ord-1036709ff8d24ddcb131c880f41056bd
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06933311B2

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