3,3,4-Trimethylpentan-1-ol → 3,3,4-Trimethylpentanal

HRID 586142노트

반응식

HRID 586142 반응식
[CH3:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[CH2:3][CH2:4][OH:5].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH3:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[CH2:3][CH:4]=[O:5]

참가 물질

4

반응물 2

HCID 124253343,3,4-Trimethylpentan-1-olHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 124253353,3,4-Trimethylpentanal

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3,3,4-Trimethylpentanol (1 equiv) is dissolved in CH2Cl2. Pyridinium chlorochromate (1.5 equiv) is added and the resulting mixture is stirred at ambient temperature. The liquid is decanted and concentrated by rotary evaporation. The residue is triturated with 1 to 1 diethyl ether/hexane and mixture is filtered and the filtrate is washed with 1 N HCl. The organic layer is dried over Na2SO4, decanted and concentrated. The aldehyde is purified by fractional distillation to yield 3,3,4-trimethylpentanal.

후처리

  1. customThe liquid is decanted
  2. concentrationconcentrated by rotary evaporation
  3. customThe residue is triturated with 1 to 1 diethyl ether/hexane and mixture
  4. filtrationis filtered
  5. washthe filtrate is washed with 1 N HCl
  6. dry with materialThe organic layer is dried over Na2SO4
  7. customdecanted
  8. concentrationconcentrated
  9. distillationThe aldehyde is purified by fractional distillation

출처 및 근거

ORD 기록
ord-c4d859fffe7a41c28f5913316149751e
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936606B2

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