Triethylamine → N-[4-({[2-(4-Bromophenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-yl]amino}-methyl)phenyl]acetamide

https://huagongshe.com/ko/reaction/586157

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	N-[4-(aminomethyl)phenyl]acetamide	HCID 15295869	—
반응물	2-(4-Bromophenyl)-5,7-dimethyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine	HCID 22329622	—
용매	1,4-Dioxane	HCID 31275	—
생성물	N-[4-({[2-(4-Bromophenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-yl]amino}-methyl)phenyl]acetamide	HCID 22329639	—

반응 조건

온도	80 °C

반응 단계

2-(4-Bromophenyl)-5,7-dimethyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]-triazine (3.7 mg, 10 mmol) is treated in dioxane (100 μl) with 4-acetylamino-benzylamine (3.3 mg, 20 mmol) and triethylamine (4 μl). The mixture is heated at 80° C. with shaking for 12 h, filtered and washed with DMSO (2×100 μl). The combined filtrates are purified chromatographically by preparative LC-MS.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06936609B2
출처 데이터셋	uspto-grants-2005_08
ORD ID	ord-220a3115004a4a9fa2dfcefbfc7be50a
출처 메모	uspto-grants-2005_08