Bis(neopentyl glycolato)diboron → HCID 22329528, 화합물

반응식

Br[C:2]1[CH:3]=[C:4]([C:8]2[C:13]([F:14])=[CH:12][C:11]([F:15])=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[B:16]1(B2OCC(C)(C)CO2)[O:21]CC(C)(C)C[O:17]1>>[F:14][C:13]1[C:8]([C:4]2[CH:3]=[C:2]([B:16]([OH:21])[OH:17])[CH:7]=[CH:6][CH:5]=2)=[N:9][CH:10]=[C:11]([F:15])[CH:12]=1

참가 물질

반응물 2

HCID 2734316Bis(neopentyl glycolato)diboron

HCID 22329520HCID 22329520, 화합물

생성물 1

HCID 22329528HCID 22329528, 화합물

실험 절차

2-(3-Bromophenyl)-3,5-difluoropyridine (80 mg, 0.30 mmol) was reacted with bis(neopentyl glycolato)diboron (74 mg, 0.33 mmol) using the method of Example 20 to give 3-(3,5-difluoropyridin-2-yl)phenylboronic acid as a tan solid: MS (ES+) m/z 236 [M+H]+.

출처 및 근거

ORD 기록: ord-1067dd4edbfe4d279b58f3bd6b4a7e38
출처 데이터셋: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06936608B2

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