5-Chloro-2-methylphenyl isothiocyanate → 1-(5-Chloro-2-methyl-phenyl)-3-(2-methyl-benzothiazol-5-yl)-thiourea

HRID 586556

반응식

HRID 586556 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N:8]=[C:9]=[S:10])[CH:7]=1.[NH2:12][C:13]1[CH:14]=[CH:15][C:16]2[S:20][C:19]([CH3:21])=[N:18][C:17]=2[CH:22]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([NH:8][C:9]([NH:12][C:13]2[CH:14]=[CH:15][C:16]3[S:20][C:19]([CH3:21])=[N:18][C:17]=3[CH:22]=2)=[S:10])[CH:7]=1

참가 물질

3

반응물 2

HCID 295195-Chloro-2-methylphenyl isothiocyanateHCID 362295-Benzothiazolamine, 2-methyl-

생성물 1

HCID 102913861-(5-Chloro-2-methyl-phenyl)-3-(2-methyl-benzothiazol-5-yl)-thiourea수율 29.3%

실험 절차

Prepared using Method A from 4.5 g (24.5 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 4.02 g (24.5 mmol) of 5-amino-2-methylbenzothiazole to give 6.0 g of crude material. Soxhlet extraction with EtOAc gave 2.5 g of pure title compound as a tan solid (29% yield, m.p. 173-174° C.).

후처리

  1. customPrepared
  2. customto give 6.0 g of crude material
  3. extractionSoxhlet extraction with EtOAc

출처 및 근거

ORD 기록
ord-09354a4437fd4f4c904abdcf191c32b9
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936630B2

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