1-Bromo-2-butanone → Formyl(2-oxobutyl)formamide

HRID 586709노트

반응식

HRID 586709 반응식
Br[CH2:2][C:3](=[O:6])[CH2:4][CH3:5].[CH:7]([N-:9][CH:10]=[O:11])=[O:8].[Na+]>C(#N)C>[CH:7]([N:9]([CH2:2][C:3](=[O:6])[CH2:4][CH3:5])[CH:10]=[O:11])=[O:8]

참가 물질

4

반응물 2

HCID 131561-Bromo-2-butanoneHCID 10877056Sodium Diformylamide

생성물 1

HCID 20825930Formyl(2-oxobutyl)formamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of bromobutan-2-one (10 g, 66 mmol), and sodium diformylamide (6.8 g, 72 mmol) in acetonitrile (50 mL) was stirred at room temperature for 3 hours, then warmed to 35° C. for 2 hours. The mixture was stirred for a further 48 hours at room temperature, then filtered, washing through with additional acetonitrile (50 mL). The filtrate was evaporated under reduced pressure to afford the title compound as a clear oil, 9.1 g.

후처리

  1. temperaturewarmed to 35° C. for 2 hours
  2. stirringThe mixture was stirred for a further 48 hours at room temperature
  3. filtrationfiltered
  4. washwashing through with additional acetonitrile (50 mL)
  5. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-94d1bfeda9b647bb942d34ad6ffce6df
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936619B2

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