Ammonia → 2-Amino-6-fluoro-4-methoxybenzonitrile

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[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[C:6](F)[C:3]=1[C:4]#[N:5].[NH3:13]>>[NH2:13][C:6]1[CH:7]=[C:8]([O:10][CH3:11])[CH:9]=[C:2]([F:1])[C:3]=1[C:4]#[N:5]

참가 물질

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HCID 222Ammonia

HCID 27787722,6-Difluoro-4-methoxybenzonitrile

생성물 1

HCID 223351772-Amino-6-fluoro-4-methoxybenzonitrile

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온도: 140 °C

실험 절차

2,6-Difluoro-4-methoxy-benzonitrile (Mol. Cryst. Liq. Cryst. 1989, 172) (200 mg, 1.18 mmol) was dissolved in ethanolic ammonia (2M solution, 10 ml) and the mixture was heated at 140° C. in an autoclave for 16 hours. The reaction mixture was cooled to room temperature and the solvent was evaporated under reduced pressure. The residue was purified by chromatography on silica gel using ethyl acetate in pentane as eluant (20:80) to give the title compound as a white solid (165 mg). LRMS: m/z (ES+) 189 [MNa+]

후처리

temperatureThe reaction mixture was cooled to room temperature
customthe solvent was evaporated under reduced pressure
customThe residue was purified by chromatography on silica gel

출처 및 근거

ORD 기록: ord-d498532a0f0a47ce9d470456ed8f59b9
출처 데이터셋: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06936619B2

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