Ammonium Hydroxide → HCID 178418808, 화합물

HRID 586779

반응식

HRID 586779 반응식
[CH2:1]([S:7][S:8][CH2:9][C@H:10]([NH2:14])[C:11]([OH:13])=[O:12])[C@H:2]([NH2:6])[C:3]([OH:5])=[O:4].S(O)(O)(=O)=O.CO[C:22](=[NH:24])[NH2:23].[OH-].[NH4+:26]>>[NH:23]([CH:1]([S:7][S:8][CH2:9][C@H:10]([NH2:14])[C:11]([OH:13])=[O:12])[C@H:2]([NH2:6])[C:3]([OH:5])=[O:4])[C:22]([NH2:24])=[NH:26]

참가 물질

4

반응물 3

HCID 14923Ammonium HydroxideHCID 67678(-)-CystineHCID 169039Carbamimidic acid, methyl ester, sulfate (1:1)

생성물 1

HCID 178418808HCID 178418808, 화합물

반응 조건

온도
60 °C

실험 절차

To a solution of cystine (1 gm, 4.2 mmol) in ammonium hydroxide (10 mL) in a screw-capped vial was added O-methylisourea hydrogen sulfate (1.8 gm, 10 mmol). The vial was sealed and heated to 60° C. for 16 h. The solution was then cooled and the ammonium hydroxide was removed by rotary evaporation. The solid was then dissolved in water (20 mL), filtered through a cotton plug. The product was then isolated by ion exchange chromatography using Bio-Rex 70 resin and eluting with hydrochloric acid (100 mM).

후처리

  1. customThe vial was sealed
  2. temperatureThe solution was then cooled
  3. customthe ammonium hydroxide was removed by rotary evaporation
  4. dissolutionThe solid was then dissolved in water (20 mL)
  5. filtrationfiltered through a cotton plug
  6. customThe product was then isolated by ion exchange chromatography
  7. washeluting with hydrochloric acid (100 mM)

출처 및 근거

ORD 기록
ord-f766fc4bf6e44144bf48a6254ad741d1
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936729B2

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