Triethylamine → N-(2-Fluoro-1,1-dimethylethyl)-2,4-difluorobenzamide

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	2,4-Difluorobenzoic acid	HCID 74102	—
반응물	1-Hydroxybenzotriazole	HCID 75771	—
반응물	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
반응물	1-Fluoro-2-methylpropan-2-amine hydrochloride	HCID 13935251	—
용매	Dichloromethane	HCID 6344	—
생성물	N-(2-Fluoro-1,1-dimethylethyl)-2,4-difluorobenzamide	HCID 10198515	44%

반응 단계

WSC HCl (1.15 g, 6 mmol) was added to a mixture of 2,4-difluorobenzoic acid (0.95 g, 6 mmol), 2-fluoro-1,1-dimethylethylamine hydrochloride (J. Med. Chem., 34, 29-37(1991): 0.77 g, 6 mmol), HOBt (0.81 g, 6 mmol) and triethylamine (0.91 g, 9 mmol) in methylene chloride (15 ml), and stirred at room temperature for 3 hours. The reaction mixture was concentrated, diluted with ethyl acetate and washed with saturated aqueous NaHCO3, 1N hydrochloric acid, saturated aqueous NaHCO3 and brine, successively, dried over MgSO4 and concentrated under a reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate=20/1) to give the title compound (0.61 g: 44%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06936736B2
출처 데이터셋	uspto-grants-2005_08
ORD ID	ord-4ea4f38997dd4427b20ebededd071221
출처 메모	uspto-grants-2005_08