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Ammonia → 2-[4-[(2-amino-5-butoxy-4-iminocyclohexa-2,5-dien-1-ylidene)amino]-N-(2-hydroxyethyl)anilino]ethanol

HRID 587101
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HRID 587101 반응식
Cl.[CH2:2]([N:4](C(C)C)[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[CH3:3].Cl.Cl.[CH2:17]([O:21][C:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][C:23]=1[NH2:29])[CH2:18][CH2:19][CH3:20].N.[OH:31]O.[CH2:33]([OH:35])[CH3:34]>O>[NH2:28][C:25]1[C:26](=[N:11][C:8]2[CH:9]=[CH:10][C:5]([N:4]([CH2:2][CH2:3][OH:31])[CH2:34][CH2:33][OH:35])=[CH:6][CH:7]=2)[CH:27]=[C:22]([O:21][CH2:17][CH2:18][CH2:19][CH3:20])[C:23](=[NH:29])[CH:24]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 222AmmoniaHCID 702EthanolHCID 784Hydrogen PeroxideHCID 1536941,3-Benzenediamine, 4-butoxy-, dihydrochlorideHCID 16211123N-Ethyl-N-isopropyl-p-phenylenediamine hydrochloride

생성물 1

HCID 1406628362-[4-[(2-amino-5-butoxy-4-iminocyclohexa-2,5-dien-1-ylidene)amino]-N-(2-hydroxyethyl)anilino]ethanol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 0.925 g (0.003 mol) of N-ethyl-N-isopropyl-4-aminoaniline hydrochloride and 0.76 g (0.003 mol) of 4-butoxybenzene-1,3-diamine dihydrochloride in 2 ml of water and 6 ml of ethanol, brought to pH 9.5 with 20% aqueous ammonia, are added 10.2 ml of 6% aqueous hydrogen peroxide solution. After stirring for 24 hours at room temperature, the ethanol is removed and the coupling product formed is extracted with butanol. After removal of the butanol under vacuum, the gummy residue is taken up in ethyl acetate and then in ether. 0.470 g of 2-[[4-(2-amino-5-butoxy-4-iminocyclohexa-2,5-dienylideneamino)phenyl](2-hydroxyethyl)amino]ethanol 10 is obtained in the form of a blue-black powder after drying.

후처리

  1. customthe ethanol is removed
  2. customthe coupling product formed
  3. extractionis extracted with butanol
  4. customAfter removal of the butanol under vacuum

출처 및 근거

ORD 기록
ord-00d1f0ebe0fa4bef90831e3d948b2145
출처 데이터셋
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09226883B2

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