Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenesulfonamide, 3-amino- → 3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenesulfonamide, 3-amino- | HCID 7377 | — |
| 반응물 | 2,4-Dichloro-1,3,5-triazine | HCID 17810 | — |
| 반응물 | 3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide | HCID 86679822 | — |
| 생성물 | 3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenesulfonamide | HCID 86679823 | 35% |
반응 단계
A2 was prepared following the general procedure reported for A1 using 2,4-dichloro-1,3,5-triazine and 3-aminobenzenesulfonamide as reacting agents. The crude product was purified by flash chromatography on silica gel (cHex/EtOAc=20:1 to 1:20) to yield the desired product A2 as a white solid (35%). 1H NMR (400 MHz, d6-DMSO, 300K) δ 7.41 (s, 2H), 7.59 (m, 2H), 7.85 (d, J=6.9 Hz, 1H), 8.21 (br.s, 1H), 8.69 (s, 1H), 11.02 (s, 1H). MS (ES) C9H8ClN5O2S requires: 285. found: 286 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09226929B2 |
| 출처 데이터셋 | uspto-grants-2016_01 |
| ORD ID | ord-845ce6ba1a8e45dd8da4c4971f129d4e |
| 출처 메모 | uspto-grants-2016_01 |