3-(Morpholin-4-yl)propanoic acid → [(3S,4R)-4-(4-chloro-phenyl)-1-(3-morpholin-4-yl-propionyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester

HRID 587359

반응식

HRID 587359 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:24])[N:10]([C@H:12]2[C@H:16]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:15][NH:14][CH2:13]2)[CH3:11])=[CH:4][CH:3]=1.[N:25]1([CH2:31][CH2:32][C:33](O)=[O:34])[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:24])[N:10]([C@H:12]2[C@H:16]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:15][N:14]([C:33](=[O:34])[CH2:32][CH2:31][N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)[CH2:13]2)[CH3:11])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 4108133-(Morpholin-4-yl)propanoic acidHCID 67233751[(3S,4R)-4-(4-chloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester

생성물 1

HCID 58303193[(3S,4R)-4-(4-chloro-phenyl)-1-(3-morpholin-4-yl-propionyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester

실험 절차

In analogy to the procedure described for the synthesis of example 44 (step c), the title compound [(3S,4R)-4-(4-chloro-phenyl)-1-(3-morpholin-4-yl-propionyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester was prepared from [(3S,4R)-4-(4-chloro-phenyl)-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester using 3-morpholin-4-yl-propionic acid instead of 1-methylcyclopropane-1-carboxylic acid and was obtained as a white solid. MS m/e: 490.2 [M+H]+.

후처리

  1. customIn analogy to the procedure described for the synthesis of example 44 (step c)
  2. customwas obtained as a white solid

출처 및 근거

ORD 기록
ord-bbbc0b6806f3493e90a9e5c02a9636ae
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09226916B2

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