Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 587489생성일: 2026년 10월 25일
Sodium Bicarbonate → 3-[1-(3H-imidazo[4,5-b]pyridin-2-yl)-2,3-dihydro-1H-indol-5-yl]-1-(1-methylethyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
https://huagongshe.com/reaction/587489
참여 물질
| 역할 | 이름 | HCID | 투입량 |
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| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 3-(2,3-dihydro-1H-indol-5-yl)-1-(1-methylethyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one | HCID 58577255 | — |
| 반응물 | HCID 178478314 | HCID 178478314 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 3-[1-(3H-imidazo[4,5-b]pyridin-2-yl)-2,3-dihydro-1H-indol-5-yl]-1-(1-methylethyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one | HCID 178456589 | 5.4% |
반응 단계
A mixture of 3-(2,3-dihydro-1H-indol-5-yl)-1-(1-methylethyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (200 mg) and 2-chloro-3H-imidazo[4,5-b]pyridine (115 mg) in NMP (4 mL) was stirred at 140° C. for 1.5 h, treated with saturated NaHCO3, and extracted with AcOEt. The organic layer was dried over MgSO4, passed through celite pad covered with activated carbon and concentrated in vacuo. The residue was purified by prep. HPLC. The product was crystallized from EtOH/hexane to give the title compound (15.0 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09226921B2 |
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| 출처 데이터셋 | uspto-grants-2016_01 |
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| ORD ID | ord-642d2800f65c44b98b78fba1411de297 |
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| 출처 메모 | uspto-grants-2016_01 |
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