참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzoic acid, 5-chloro-2-hydroxy-, methyl ester | HCID 77684 | — |
| 반응물 | 3-Bromocyclohexene | HCID 137057 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 2-(cyclohexen-3-yloxy)-5-chlorobenzoate | HCID 14621138 | — |
반응 단계
A mixture of 18.6 g of methyl 5-chlorosalicylate, 28 g of K2CO3 and 20 g of 3-bromocyclohexene in 200 ml of DMF is stirred at 90° C. overnight. The mixture is then Poured into water, extracted with ethyl acetate, washed with water, dried over magnesium sulfate and evaporated to dryness to obtain crude product. This is purified by flash chromatography using hexane as the eluent to give pure methyl 2-(cyclohexen-3-yloxy)-5-chlorobenzoate as the first fraction which is used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05246942 |
|---|
| 출처 데이터셋 | uspto-grants-1993_09 |
|---|
| ORD ID | ord-e0690a28b3d54980b51fc455d392fbaf |
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| 출처 메모 | uspto-grants-1993_09 |
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